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开放性破裂腹主动脉瘤修复术后幸存者的健康相关生活质量:一项匹配对照队列研究。

Health-related quality of life in survivors of open ruptured abdominal aortic aneurysm repair: a matched, controlled cohort study.

作者信息

Hill Andrew B, Palerme Louis-Philippe, Brandys Tim, Lewis Ron, Steinmetz Oren K

机构信息

Division of Vascular Surgery, Department of Surgery, The University of Ottawa, Ottawa Hospital, Ottawa, Ontario, Canada.

出版信息

J Vasc Surg. 2007 Aug;46(2):223-9. doi: 10.1016/j.jvs.2007.04.033.

Abstract

OBJECTIVE

The objective of this study was to document the health-related quality of life (HRQOL) for patients who survived operative repair of a ruptured abdominal aortic aneurysm (RAAA) and to compare this with a matched group of patients who survived elective operative repair of an abdominal aortic aneurysm (EAAA).

METHODS

A matched, controlled cohort study of HRQOL was used to compare patients surviving RAAA with an EAAA control group. The study was conducted at two university-affiliated vascular tertiary care referral centers. Survivors of RAAA and EAAA during an 8.5-year period were identified and followed up. The RAAA and EAAA control patients were matched for age, serum creatinine concentration, gender, and duration of follow-up since surgery. HRQOL was measured with the Medical Outcomes Study Short Form-36 Health Survey (SF-36). Scores for the EAAA and RAAA cohorts were also compared with age-corrected SF-36 population scores.

RESULTS

Of 267 patients operated for RAAA during the study period, 130 (49%) survived to hospital discharge. Death after discharge was documented in 35 patients, leaving a potential study population of 95 RAAA survivors. Thirteen were lost to follow-up, seven refused to participate, and four patients were not able to participate. The SF-36 was completed by 71 RAAA patients (75% of surviving RAAA patients). The 71 RAAA survivors and 189 EAAA control patients were similar for seven of eight domains of the SF-36: Physical Function, Role-Physical, Bodily Pain, General Health, Vitality, Mental Health, and Role-Emotional. There was also no difference in the Physical Health Summary and Mental Health Summary scores. The social function component of the SF-36 demonstrated a statistically significant decline in the EAAA group. Both the EAAA and RAAA SF-36 individual and summary scores compared favorably with population norms that were adjusted only for age.

CONCLUSION

Long-term survivors of RAAA enjoy a HRQOL that does not differ significantly from EAAA survivors. Scores for both groups compare favorably with population scores adjusted only for age.

摘要

目的

本研究的目的是记录腹主动脉瘤破裂(RAAA)手术修复术后存活患者的健康相关生活质量(HRQOL),并将其与腹主动脉瘤择期手术修复(EAAA)术后存活的匹配患者组进行比较。

方法

采用一项匹配的、对照的HRQOL队列研究,将RAAA存活患者与EAAA对照组进行比较。该研究在两个大学附属血管三级护理转诊中心进行。确定并随访了8.5年期间RAAA和EAAA的幸存者。RAAA和EAAA对照患者在年龄、血清肌酐浓度、性别以及术后随访时间方面进行匹配。使用医学结局研究简明健康调查(SF-36)测量HRQOL。还将EAAA和RAAA队列的得分与年龄校正后的SF-36人群得分进行比较。

结果

在研究期间接受RAAA手术的267例患者中,130例(49%)存活至出院。35例患者出院后死亡,留下95例RAAA存活患者作为潜在研究人群。13例失访,7例拒绝参与,4例患者无法参与。71例RAAA患者(存活RAAA患者的75%)完成了SF-36。71例RAAA幸存者和189例EAAA对照患者在SF-36的八个领域中的七个领域相似:身体功能、角色-身体、躯体疼痛、总体健康、活力、心理健康和角色-情感。身体健康总结和心理健康总结得分也没有差异。SF-36的社会功能成分在EAAA组中显示出统计学上的显著下降。EAAA和RAAA的SF-36个体得分和总结得分与仅根据年龄调整的人群规范相比均较好。

结论

RAAA的长期幸存者的HRQOL与EAAA幸存者没有显著差异。两组得分与仅根据年龄调整的人群得分相比均较好。

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