Paus R
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510.
Med Hypotheses. 1991 Sep;36(1):33-42. doi: 10.1016/0306-9877(91)90161-q.
Despite its extensive repertoire of biological activities, which include the growth- and osmoregulation of epithelial tissues as well as immunoregulatory properties, the potential significance of the pituitary hormone prolactin (PRL) for human skin biology and pathology has yet to be fully appreciated. In this essay, the hypothesis is presented that PRL acts as a neuroendocrine modulator of skin epithelial cell proliferation and of the skin immune system by forming a 'prolactin-circuit' between the central nervous system and the skin. Binding to specific skin receptors, modulation of cytokine release in the skin, and stimulation of somatomedin release by mesenchymal cells are among the suggested pathways by which PRL could affect epithelial cell growth in the skin. Potential feedback signals, arising from the skin and modifying pituitary PRL release, are briefly outlined. Centering on the role of PRL in both psoriasis and hair growth as models for studying the proposed PRL-skin connection, clinical and experimental evidence in support of this theory is discussed in the context of a 'neuroimmune-dermatological' perspective.
尽管垂体激素催乳素（PRL）具有广泛的生物学活性，包括上皮组织的生长调节和渗透调节以及免疫调节特性，但其对人类皮肤生物学和病理学的潜在重要性尚未得到充分认识。在本文中，我们提出一个假说，即PRL通过在中枢神经系统和皮肤之间形成一个“催乳素回路”，作为皮肤上皮细胞增殖和皮肤免疫系统的神经内分泌调节剂。与特定皮肤受体结合、调节皮肤中细胞因子的释放以及间充质细胞刺激生长激素释放因子的释放，是PRL可能影响皮肤上皮细胞生长的几种途径。本文简要概述了来自皮肤并调节垂体PRL释放的潜在反馈信号。以PRL在银屑病和毛发生长中的作用作为研究PRL与皮肤联系的模型，从“神经免疫皮肤病学”的角度讨论了支持这一理论的临床和实验证据。
