Nicholson James M, Yeager David L, Macones George
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Ann Fam Med. 2007 Jul-Aug;5(4):310-9. doi: 10.1370/afm.706.
Annual cesarean delivery rates in North America are increasing. Despite the morbidity associated with cesarean delivery, a safe preventive strategy to reduce the use of this procedure has not been forthcoming. During the 1990s, clinicians in a rural hospital developed a method of care involving prostaglandin-assisted preventive labor induction. An inverse relationship was noted between yearly hospital rates of labor induction and cesarean delivery. The purpose of our study was to compare cesarean delivery rates between practitioners who often used preventive induction and practitioners who did not, while controlling for patient mix and differences in practice style.
Between 1993 and 1997, different hospital practitioners used risk-guided prostaglandin-assisted preventive labor induction with differing intensity. We used a retrospective cohort design, based on the practitioner providing prenatal care, to compare birth outcomes in women exposed to this alternative method of care with those in women not exposed. Multiple logistic regression analysis controlled for patient characteristics and clustering by practitioner.
The exposed group (n = 794), as compared with the nonexposed group (n = 1,075), had a higher labor induction rate (31.4% vs 20.4%, P <.001), a greater use of prostaglandin E2 (23.3% vs 15.7%, P <.001), and a lower cesarean delivery rate (5.3% vs 11.8%, P <.001). Adjustment for cluster effects, patient characteristics, and the use of epidural analgesia did not eliminate the significant association between exposure to this preventive method of care and a lower cesarean delivery rate. Rates of other adverse birth outcomes were either unchanged or reduced in the exposed group.
A preventive approach to reducing cesarean deliveries may be possible. This study found that practitioners who often used risk-guided, prostaglandin-assisted labor induction had a lower cesarean delivery rate without increases in rates of other adverse birth outcomes. Randomized controlled trials of this method of care are warranted.
北美地区剖宫产年发生率呈上升趋势。尽管剖宫产存在相关并发症,但尚未出现安全的预防策略来减少该手术的使用。在20世纪90年代,一家乡村医院的临床医生开发了一种护理方法,包括使用前列腺素辅助预防性引产。研究发现每年医院引产率与剖宫产率之间呈负相关。我们研究的目的是在控制患者构成和医疗方式差异的同时,比较经常使用预防性引产的医生与不使用预防性引产的医生的剖宫产率。
1993年至1997年间,不同的医院医生以不同强度使用风险导向的前列腺素辅助预防性引产。我们采用回顾性队列设计,根据提供产前护理的医生进行分组,比较接受这种替代护理方法的女性与未接受该方法的女性的分娩结局。多因素logistic回归分析对患者特征和医生聚类进行了控制。
与未暴露组(n = 1075)相比,暴露组(n = 794)引产率更高(31.4% 对20.4%,P <.001),前列腺素E2的使用更多(23.3% 对15.7%,P <.001),剖宫产率更低(5.3% 对11.8%,P <.001)。对聚类效应、患者特征和硬膜外镇痛的使用进行调整后,并未消除接受这种预防性护理方法与较低剖宫产率之间的显著关联。暴露组其他不良分娩结局的发生率要么未变,要么有所降低。
降低剖宫产率的预防方法可能是可行的。本研究发现,经常使用风险导向的前列腺素辅助引产的医生剖宫产率较低,且其他不良分娩结局的发生率并未增加。有必要对这种护理方法进行随机对照试验。