Majewska Urszula, Banaś Dariusz, Braziewicz Janusz, Góźdź Stanisław, Kubala-Kukuś Aldona, Kucharzewski Marek
Institute of Physics, Swietokrzyska Academy, Swietokrzyska 15, 25-406 Kielce, Poland.
Phys Med Biol. 2007 Jul 7;52(13):3895-911. doi: 10.1088/0031-9155/52/13/016. Epub 2007 Jun 4.
The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intestine (colon) have been determined. In the cases when the element concentration has not been determined in all samples the Kaplan-Meier method has been used for the reconstruction of the original concentration distributions and estimation of the true mean concentrations and medians. Finally, the log-rank test has been applied to compare the elemental concentration distributions between cancerous and benign tissues of the same organ, between cancerous tissues and between benign tissues taken from different organs. Comparing benign and malignant neoplastic tissues, statistically significant differences have been found between Fe and Se concentration distributions of breast as well as for Cu and Zn in the case of lung tissues and in the case of colon tissues for Zn. The concentrations of all elements have been found to be statistically different in cancer tissues as well as in benign ones when comparing the different organs, i.e. groups 'breast-colon' and 'breast-lung'. Concentrations of Fe and Cu have been found to be statistically different in lung and colon cancerous tissues. For benign tissues of lung and colon a statistically significant difference has been found only for Zn.
已测定了乳腺、肺和肠（结肠）的癌组织和良性组织中Fe、Cu、Zn和Se的浓度。在并非所有样本都测定了元素浓度的情况下，采用Kaplan-Meier方法来重建原始浓度分布，并估计真实的平均浓度和中位数。最后，应用对数秩检验来比较同一器官的癌组织和良性组织之间、癌组织之间以及取自不同器官的良性组织之间的元素浓度分布。比较良性和恶性肿瘤组织时，发现乳腺的Fe和Se浓度分布之间以及肺组织和结肠组织中Cu和Zn的浓度分布之间存在统计学显著差异。在比较不同器官（即“乳腺-结肠”和“乳腺-肺”组）时，发现所有元素的浓度在癌组织和良性组织中均存在统计学差异。发现肺和结肠癌组织中Fe和Cu的浓度存在统计学差异。对于肺和结肠的良性组织，仅发现Zn存在统计学显著差异。
