Kim Bong Seok, Isaacson David, Xia Hongjun, Kao Tzu-Jen, Newell Jonathan C, Saulnier Gary J
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Physiol Meas. 2007 Jul;28(7):S237-46. doi: 10.1088/0967-3334/28/7/S17. Epub 2007 Jun 26.
Research on freshly-excised malignant breast tissues and surrounding normal tissues in an in vitro impedance cell has shown that breast tumors have different conductivity and permittivity from normal or non-malignant tissues. This contrast may provide a basis for breast cancer detection using electrical impedance imaging. This paper describes a procedure for collecting electrical impedance spectroscopy data simultaneously and in register with tomosynthesis data from patients. We describe the methods used to analyze the data in order to determine if the electrodes are making contact with the breast of the patient. Canonical voltage patterns are applied and used to synthesize the data that would have resulted from constant voltage patterns applied to each of two parallel mammography plates. A type of Cole-Cole plot is generated and displayed from each of the currents measured on each of the electrodes for each of the frequencies (5, 10, 30, 100 and 300 kHz) of applied voltages. We illustrate the potential usefulness of these displays in distinguishing breast cancer from benign lesions with the Cole-Cole plots for two patients--one having cancer and one having a benign lesion--by comparing these graphs with electrical impedance spectra previously found by Jossinet and Schmitt in tissue samples taken from a variety of patients.
在体外阻抗细胞中对新鲜切除的恶性乳腺组织及周围正常组织进行的研究表明，乳腺肿瘤与正常或非恶性组织具有不同的电导率和电容率。这种差异可为利用电阻抗成像检测乳腺癌提供依据。本文描述了一种同时收集电阻抗光谱数据并与患者断层合成数据配准的程序。我们描述了用于分析数据的方法，以确定电极是否与患者的乳房接触。应用规范电压模式并用于合成将由施加到两个平行乳房X线摄影板中每一个的恒定电压模式产生的数据。针对施加电压的每个频率（5、10、30、100和300 kHz），从每个电极上测量的每个电流生成并显示一种类型的科尔 - 科尔图。通过将这些图形与Jossinet和Schmitt先前在从各种患者采集的组织样本中发现的电阻抗谱进行比较，我们用两名患者（一名患有癌症，一名患有良性病变）的科尔 - 科尔图说明了这些显示在区分乳腺癌与良性病变方面的潜在用途。
