Bhargava P
Department of Dermatology, STD and Leprosy, S.M.S. Medical College, Jaipur-302 004, India.
Indian J Dermatol Venereol Leprol. 2001 Nov-Dec;67(6):317-9.
Sixty patients of anticonvulsant hypersensitivity syndrome were studied. Fever and skin rash were present in all patients with peripheral blood leucocytosis and eosinophilia in 30 patients. Phenytoin was the commonest offending drug(39 patients) followed by carbamazepine (19 patients). AHS appeared after 2-12 weeks of the intake of offending drugs. Head injury was the primary illness in 43 patients (70 per cent) followed by brain tumors (9 patients). Cross reactivity between phenytoin and carbamazepine was seen in 3 patients. Most patients recovered well with withdrawal of the offending drugs and treatment with topical corticosteroids and antihistamines. There was only one fatality.
对60例抗惊厥药超敏反应综合征患者进行了研究。所有患者均有发热和皮疹，30例患者外周血白细胞增多且嗜酸性粒细胞增多。苯妥英是最常见的致病药物（39例），其次是卡马西平（19例）。抗惊厥药超敏反应综合征在摄入致病药物2至12周后出现。43例患者（70%）的原发性疾病为头部损伤，其次是脑肿瘤（9例）。3例患者出现苯妥英和卡马西平之间的交叉反应。大多数患者停用致病药物并外用糖皮质激素和抗组胺药治疗后恢复良好。仅有1例死亡。
