Margineanu M, Marches R, Dima S, Cialacu V, Kozma E, Savi G, Stavri H, Badea E, Bancu A, Mota G
Department of Immunology, Babes Institute, Bucharest, Romania.
Neoplasma. 1991;38(6):633-8.
Two multivalent immunotoxins (ITs) with cytotoxic potential against Thy 1.2-expressing tumor cells were used in association with mouse interleukin 2 (IL2) for treatment of mice bearing ascitic EL4 lymphomas. The combined treatment, ITs + IL2, induced an enhanced antitumor effect revealed by a significant prolongation of the survival time of mice as compared to the simple treatment with ITs or IL2 alone. According to the survival of mice treated by combined therapy, the proportion of killed tumor cells rose up to 94% as resulted from the dose-dependent curve of the survival of nontreated mice versus the number of tumor cells inoculated.
两种对表达Thy 1.2的肿瘤细胞具有细胞毒性潜力的多价免疫毒素（ITs）与小鼠白细胞介素2（IL2）联合用于治疗患有腹水型EL4淋巴瘤的小鼠。与单独使用ITs或IL2的单一治疗相比，联合治疗（ITs + IL2）诱导了增强的抗肿瘤作用，表现为小鼠存活时间显著延长。根据联合治疗小鼠的存活情况，从未经治疗小鼠的存活剂量依赖性曲线与接种肿瘤细胞数量的关系来看，杀死的肿瘤细胞比例上升至94%。
