Marches R, Mota G, Margineanu M, Stavri H, Savi G, Nicolae M, Bancu A, Moraru I
Department of Immunology, Babes Institute, Bucharest, Romania.
Neoplasma. 1990;37(5):573-8.
C57BL/6 mice with EL4 leukemia cells in ascitic form were intraperitoneally treated with ricin A chain-multivalent antibody immunotoxins. The immunotoxins containing rabbit IgG anti-Thy 1.2 antibodies complemented by protein A of Staphylococcus aureus were able to interact specifically with the target cells and to induce an antitumor effect as revealed by an increase in survival time of the mice. No apparent secondary effects consecutive to a cytotoxic action on the normal Thy 1.2 antigen bearing cells were observed with the immunotoxin doses used.
将携带腹水形式EL4白血病细胞的C57BL/6小鼠腹腔注射蓖麻毒素A链-多价抗体免疫毒素进行治疗。含有兔抗Thy 1.2 IgG抗体并由金黄色葡萄球菌蛋白A补充的免疫毒素能够与靶细胞特异性相互作用，并通过小鼠存活时间的延长显示出诱导抗肿瘤作用。在所使用的免疫毒素剂量下，未观察到对正常携带Thy 1.2抗原细胞的细胞毒性作用所导致的明显继发效应。
