Bresci G, Piccinocchi M, Banti S
Divisione di Gastroenterologia, USL n. 12, Pisa.
Minerva Med. 1991 Nov;82(11):753-5.
The aim of the study was to assess the efficacy and tolerance of the use of reduced GSH in patients suffering from alcoholic diseases of the liver. Eighty patients were randomly divided into two matched groups and treated for 30 days with 300 mg of reduced GSH or 10 mg of vitamin K. Clinical symptoms and the main indices of hepatic function were assessed before and after treatment. At the end of the study all patients had improved, but the group treated with reduced GSH showed a greater improvement of hepatic function indices (SAT, ALT, gamma-GT) which was statistically significant in comparison to that found in the vitamin K treatment group.
该研究的目的是评估还原型谷胱甘肽（GSH）用于患有酒精性肝病患者的疗效及耐受性。80名患者被随机分为两个匹配组，分别用300毫克还原型谷胱甘肽或10毫克维生素K治疗30天。在治疗前后评估临床症状及肝功能的主要指标。研究结束时所有患者均有改善，但用还原型谷胱甘肽治疗的组肝功能指标（血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、γ-谷氨酰转移酶）改善更大，与维生素K治疗组相比具有统计学意义。
