Tarantino G, Morelli L, Califano C
Istituto di Medicina Interna e Malattie Dismetaboliche, II Facoltà di Medicina e Chirurgia, Università di Napoli.
Riv Eur Sci Med Farmacol. 1990 Apr;12(2):109-17.
Fatty liver can be determined by chronic abuse of alcohol, by means of direct action of the same on the level of membrane's proteins. The UDPG restores the levels of a membrane's component, the phosphoribosylpyrophosphate (PRPP), which normally results reduced in cellular cultures of rat's liver, after the addition of alcohol. It has been made a study on 40 patients (27 men and 13 women age medium 54 years) alcoholics for at least 1 year with a quantity of ethanol ingested less than 1 g gamma/die/kg of body weight with alternated values of serum GOT, GPT and gamma-GT and clinical aspects of a modest alcoholic hepatopathy, assigning through, at random in double blind, two groups of treatment: the first one with UDPG (400 mg/im/die for 30 days) the second one with placebo. It has been considered like variable of therapeutic effect the difference between basal value and the result at the end of treatment of these serum enzymes, it has been applied the Student's t test for the evaluation of the difference between treatments. It has been shown in the groups of patients analyzed with UDPG (not the group of placebo) reduction extremely significant for the gamma-GT (p = 0.00032) and GOT (p = 0.0138). In 5 treated cases, after an hepatic ultrasound imaging of comparison, at the end of the treatment, it has been demonstrated an apparent improvement of thickening of the echos; only 3/40 of the patients have certainly stopped to ingest alcoholic drinks.
脂肪肝可由长期酗酒导致，酒精通过直接作用于膜蛋白水平引发。尿苷二磷酸葡萄糖（UDPG）可恢复膜成分磷酸核糖焦磷酸（PRPP）的水平，在大鼠肝脏细胞培养中加入酒精后，PRPP水平通常会降低。对40名患者（27名男性和13名女性，平均年龄54岁）进行了研究，这些患者酗酒至少1年，每日摄入乙醇量低于1克/千克体重，血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）和γ-谷氨酰转移酶（γ-GT）值交替变化，且有轻度酒精性肝病的临床症状。通过双盲随机分组，将患者分为两组进行治疗：第一组使用UDPG（400毫克/皮下注射/天，共30天），第二组使用安慰剂。将这些血清酶治疗结束时的结果与基础值之间的差异作为治疗效果变量，应用学生t检验评估治疗组间差异。结果显示，在使用UDPG治疗的患者组（而非安慰剂组）中，γ-GT（p = 0.00032）和GOT（p = 0.0138）显著降低。在5例接受治疗的病例中，治疗结束后经肝脏超声成像对比，显示回声增厚有明显改善；40名患者中只有3人肯定停止了饮酒。
