Lay P Chase, Bass Richard, Lin Sandra Y
Department of Otolaryngology--Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
Otolaryngol Head Neck Surg. 2007 Aug;137(2):243-5. doi: 10.1016/j.otohns.2007.02.012.
To study the risks of vial contamination and infection associated with immunotherapy vial mixing and injection.
Retrospective review of patient immunotherapy records from January 2000-June 2006.
Tertiary care outpatient otolaryngology clinic.
Two hundred seventy-two patients were given 26,795 injections (average of 98.5 injections per patient). Three hundred ninety-nine total local reactions were reported by the subjects (1.49%; 95% CI 1.34%-1.63%). The majority (82%) of the local reactions occurred during escalation dosing. There were 23 episodes of wheezing or shortness of breath after injections (9.6 of 10,000). No patients experienced anaphylaxis. There was no documented skin or systemic infections as a result of the allergy injections. None of the patients experienced fever, discharge from the injection site, cellulitis, or required antibiotics.
This review of immunotherapy records revealed no complications of infection from the preparation and administration of immunotherapy performed in an outpatient clinic.
研究免疫治疗药瓶混合及注射相关的药瓶污染和感染风险。
回顾性分析2000年1月至2006年6月患者的免疫治疗记录。
三级护理门诊耳鼻喉科诊所。
272例患者共接受了26795次注射（平均每位患者98.5次注射）。受试者共报告了399次局部反应（1.49%；95%置信区间1.34%-1.63%）。大多数（82%）局部反应发生在剂量递增期间。注射后有23例出现喘息或呼吸急促（万分之9.6）。无患者发生过敏反应。无记录表明因过敏注射导致皮肤或全身感染。所有患者均未出现发热、注射部位渗液、蜂窝织炎或需要使用抗生素的情况。
本次对免疫治疗记录的回顾显示，门诊进行免疫治疗的制备和给药未出现感染并发症。
