Nelson B L, Dupont L A, Reid M J
Ann Allergy. 1986 Apr;56(4):331-4.
To assess the relative risk of local and systemic reactions to injections of pollen extracts and to examine the predictive value of these local reactions for systemic reactions, a prospective survey of local and systemic reactions was performed from October 1981 to June 1983 at a large military allergy clinic. Four hundred and sixteen patients received 26,645 injections of pollen extracts. Of the total, 25,508 injections (95.7%) were not associated with reactions, 1,055 injections (4.0%) were associated with local reactions (669, less than 2 cm in diameter; 279, 2 to 5 cm; and 107 greater than 5 cm), and 82 injections (0.3%) were associated with systemic reactions. Seventy patients experienced 82 systemic reactions. Of these, 25 (36%) had no prior local reactions. Eighteen males and 52 females had systemic reactions. The sensitivity of local reactions as a predictor of systemic reactions was 64%, the specificity was 1.2%, the positive predictive value was 12%, and the negative predictive value was 14%. Proportionally, more women than men experienced systemic reactions, P less than 0.05. We made the following conclusions. Most injections of pollen extracts were not associated with local or systemic reactions. The majority of reactions were local. The presence of local reactions was not helpful in predicting which patients would develop systemic reactions. Women appeared to be at greater risk for systemic reactions than men.
为评估注射花粉提取物后发生局部和全身反应的相对风险，并检验这些局部反应对全身反应的预测价值，1981年10月至1983年6月在一家大型军事过敏诊所对局部和全身反应进行了一项前瞻性调查。416名患者接受了26645次花粉提取物注射。其中，25508次注射（95.7%）未出现反应，1055次注射（4.0%）出现局部反应（669次，直径小于2厘米；279次，2至5厘米；107次大于5厘米），82次注射（0.3%）出现全身反应。70名患者经历了82次全身反应。其中，25名（36%）之前没有局部反应。18名男性和52名女性出现全身反应。局部反应作为全身反应预测指标的敏感性为64%，特异性为1.2%，阳性预测值为12%，阴性预测值为14%。按比例计算，出现全身反应的女性多于男性，P<0.05。我们得出以下结论。大多数花粉提取物注射未出现局部或全身反应。大多数反应为局部反应。局部反应的出现无助于预测哪些患者会发生全身反应。女性发生全身反应的风险似乎高于男性。
