Bray Paul F
Division of Hematology, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, PA 19107, USA.
Hematol Oncol Clin North Am. 2007 Aug;21(4):633-45, v-vi. doi: 10.1016/j.hoc.2007.06.002.
Platelet thrombi are central to the development of most vascular ischemic events. There is marked interindividual variation in platelet responsiveness, with some subjects displaying platelet hyperreactivity. An increasing number of reports indicate that there are laboratory measures of platelet function that predict clinical thrombotic events. Some, but not all, measures of platelet function are reproducible. Platelet hyperreactivity can be assessed with multiple stimuli in multiple assays and is more likely to be present in women and in subjects who have elevated fibrinogen levels.
血小板血栓在大多数血管缺血事件的发生发展中起核心作用。个体间血小板反应性存在显著差异，一些受试者表现出血小板高反应性。越来越多的报告表明，存在可预测临床血栓形成事件的血小板功能实验室检测指标。部分（但并非全部）血小板功能检测指标具有可重复性。血小板高反应性可通过多种检测方法中的多种刺激来评估，且在女性以及纤维蛋白原水平升高的受试者中更易出现。
