Visentin Gian Paolo, Liu Chao Yan
Department of Pediatrics, University at Buffalo, The State University of New York, 3435 Main Street BRB, Room 422, Buffalo, NY 14214, USA.
Hematol Oncol Clin North Am. 2007 Aug;21(4):685-96, vi. doi: 10.1016/j.hoc.2007.06.005.
Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs. DIT can be distinguished from idiopathic thrombocytopenic purpura, a bleeding disorder caused by thrombocytopenia not associated with a systemic disease, based on the history of drug ingestion or injection and laboratory findings. DIT disorders can be a consequence of decreased platelet production (bone marrow suppression) or accelerated platelet destruction (especially immune-mediated destruction).
药物性血小板减少症（DIT）是一种相对常见的临床病症。在发生具有临床意义的出血之前，或者在肝素引起血栓形成的情况下，必须迅速识别并停用致病药物。根据用药或注射史以及实验室检查结果，DIT可与特发性血小板减少性紫癜相鉴别，后者是一种由血小板减少引起的出血性疾病，与全身性疾病无关。DIT病症可能是血小板生成减少（骨髓抑制）或血小板破坏加速（尤其是免疫介导的破坏）的结果。
