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[成人盘状红斑狼疮]

[Adult discoid lupus erythematosus].

作者信息

Khelifa Elhem, Benmously Rym, Fenniche Samy, Marrak Hayet, Zghal Mohamed, Mokhtar Inçaf

机构信息

Service de Dermatologie. Hôpital Habib Thameur, Tunis.

出版信息

Tunis Med. 2007 Mar;85(3):205-8.

Abstract

BACKGROUND

Discoid lupus erythematosus is a particular form of systemic lupus in which manifestations are confined to the skin.

AIM

Our purpose was to evaluate the epidemiology trends, presenting clinical manifestations, therapeutic features and outcome of patients with discoid lupus erythematosus (DLE).

METHODS

It's a retrospective study, done in the dermatology department of Habib Thameur Hospital over an 8 years period. We included only the cases of DLE confirmed by the histology and/or the direct immunofluorescence.

RESULTS

We identified 26 patients mean aged 46.19 years. All of them were adults. The lesions were localized on the face for 25 patients, neck (7 patients), scalp (6) and hands (6). Eleven patients presented a generalized DLE. The mean period of follow-up was 3 years raging from 1 month to 20 years. After a 15 year evolution, 1 patient presented degeneration in squamous cell carcinoma of 2 lesions.

CONCLUSION

Unfortunately, there is still in our country a long delay before the first consultation, which, added to an absence of adequate photoprotection, can obscure the prognosis of DLE.

摘要

背景

盘状红斑狼疮是系统性红斑狼疮的一种特殊形式,其表现局限于皮肤。

目的

我们的目的是评估盘状红斑狼疮(DLE)患者的流行病学趋势、临床表现、治疗特点及预后。

方法

这是一项回顾性研究,在哈比卜·塔穆尔医院皮肤科进行,为期8年。我们仅纳入经组织学和/或直接免疫荧光确诊的DLE病例。

结果

我们确定了26例患者,平均年龄46.19岁。所有患者均为成年人。25例患者的皮损位于面部,7例位于颈部,6例位于头皮,6例位于手部。11例患者表现为泛发性DLE。平均随访期为3年,范围从1个月至20年。经过15年的病情演变,1例患者的2处皮损发生鳞状细胞癌退变。

结论

遗憾的是,在我国,首次就诊前仍有很长的延迟时间,再加上缺乏充分的光防护,可能会影响DLE的预后。

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