衰老过程中基因对前列腺解剖学变异性的影响：CYP17、SRD5A2和雄激素受体基因多态性的作用。

Genetic impact on prostate anatomical variability during ageing: role of CYP17, SRD5A2 and androgen receptor genes polymorphisms.

作者信息

Larré Stéphane, Hamadeh Hikmat, Azzouzi Abdel Rahmene, Vallancien Guy, Cochand-Priollet Beatrix, Cancel-Tassin Géraldine, Cussenot Olivier

机构信息

Centre de Recherche pour les Pathologies Prostatiques EA3104, France.

出版信息

BJU Int. 2007 Sep;100(3):679-84. doi: 10.1111/j.1464-410X.2007.07079.x.

DOI:10.1111/j.1464-410X.2007.07079.x

PMID:17669147

Abstract

OBJECTIVES

To investigate the role of genetic determinism on individual variability in age-related prostate changes, as defining 'normal' anatomy in prostate gland ageing is a challenge because the variability of changes in prostate morphology increases with age.

MATERIALS AND METHODS

We assessed the influence of androgen- and oestrogen-regulating genetic polymorphisms on age-related weight and stromal-ratio changes in the prostate, using an anatomical, autopsy-based study. We quantified weight and glandular/stromal ratio in 85 autopsy prostates from men aged > 50 years. We genotyped allelic variants of androgen-regulating genes [androgen receptor (CAG repeats) and type II 5-alpha reductase (TA repeat and V89L)] and an oestrogen-regulating gene (A1/A2 variants of the 17alpha-hydroxylase (CYP17)).

RESULTS

There was a fair negative correlation between prostate weight and the number of CAG repeats (r = -0.32, P = 0.003); the group with < or = 19 CAG repeats had heavier prostates than the > or = 20 group (P = 0.015). The stromal ratio was higher in the group with 20-23 CAG repeats (P = 0.02) and in the A2A2 group of the CYP17 polymorphism (P = 0.016) compared with the other groups mixed together.

CONCLUSION

A low number of CAG repeats is associated with higher prostate weights. The A2A2 genotype of CYP17 is associated with a higher stromal ratio.

摘要

目的

研究基因决定论在年龄相关前列腺变化个体差异中的作用，因为随着年龄增长前列腺形态变化的变异性增加，所以定义前列腺老化过程中的“正常”解剖结构具有挑战性。

材料与方法

我们采用基于尸检的解剖学研究，评估雄激素和雌激素调节基因多态性对年龄相关前列腺重量及基质比例变化的影响。我们对85例年龄大于50岁男性尸检前列腺的重量和腺/基质比例进行了量化。我们对雄激素调节基因[雄激素受体（CAG重复序列）和II型5α还原酶（TA重复序列和V89L）]以及雌激素调节基因（17α-羟化酶（CYP17）的A1/A2变体）的等位基因变体进行了基因分型。

结果

前列腺重量与CAG重复序列数量之间存在显著负相关（r = -0.32，P = 0.003）；CAG重复序列≤19的组前列腺比CAG重复序列≥20的组更重（P = 0.015）。与其他混合组相比，CAG重复序列为20 - 23的组以及CYP17多态性的A2A2组的基质比例更高（P = 0.02和P = 0.016）。