Hamadeh H, Larré S, Azzouzi A-R, Cancel-Tassin G, Vallancien G, Cochand-Priollet B, Cussenot O
CeRePP-EA3104, université Paris-VII, Paris, France.
Prog Urol. 2008 Apr;18(4):214-22. doi: 10.1016/j.purol.2007.12.014. Epub 2008 Apr 23.
The determinants of macroscopic and microscopic anatomical variants of the prostate during ageing are poorly defined. The authors evaluated the correlation between specific gene polymorphisms involved in androgen and oestrogen synthesis and gross (prostatic weight) and microscopic anatomy (stroma/epithelium ratio) of the prostate during ageing.
The prostatic weight and stromal surface area of an autopsy series of 85 men over the age of 50 were measured, then compared as a function of gene polymorphisms involved in androgen or oestrogen regulation. The following polymorphisms were studied: number of CAG repeats of the androgen receptor (AR), number of TA repeats and the V89L variant of the 5-alpha-reductase gene (SRD5A2) for androgens, and the A1A2 variant of 17-alpha-hydroxylase (CYP17) and number of TTTA repeats of the aromatase (CYP19) for oestrogens.
No correlation was observed between the number of TA repeats of the SRD5A2 gene or TTTA repeats of the CYP19 gene and anatomical parameters of the prostate. A statistically significant positive correlation was observed between age and prostate weight (r=0.21, p=0.05) and a statistically significant negative correlation was observed between prostate weight and number of CAG repeats (r=-0.32, p=0.003). The group with less than 20 CAG repeats was associated with a higher prostate weight than the other group. The stromal surface area was greater in the [20-23] CAG repeat group (p=0.02), and in the A2A2 group of CYP17 (p=0.016) than in the other groups.
A small number of CAG repeats is associated with a higher prostate weight. The mean number of CAG repeats of the androgen receptor and the A2A2 variant of the CYP17 gene are associated with a larger stromal surface area.
衰老过程中前列腺宏观和微观解剖变异的决定因素尚不清楚。作者评估了雄激素和雌激素合成相关的特定基因多态性与衰老过程中前列腺的大体特征（前列腺重量）和微观解剖结构（基质/上皮比例）之间的相关性。
对85名50岁以上男性尸检系列的前列腺重量和基质表面积进行测量，然后根据雄激素或雌激素调节相关的基因多态性进行比较。研究了以下多态性：雄激素受体（AR）的CAG重复次数、5α-还原酶基因（SRD5A2）的TA重复次数和V89L变体，以及雌激素方面17α-羟化酶（CYP17）的A1A2变体和芳香化酶（CYP19）的TTTA重复次数。
未观察到SRD5A2基因的TA重复次数或CYP19基因的TTTA重复次数与前列腺解剖参数之间的相关性。观察到年龄与前列腺重量之间存在统计学显著正相关（r = 0.21，p = 0.05），前列腺重量与CAG重复次数之间存在统计学显著负相关（r = -0.32，p = 0.003）。CAG重复次数少于20次的组比另一组的前列腺重量更高。[20 - 23] CAG重复组的基质表面积大于其他组（p = 0.02），CYP17的A2A2组的基质表面积也大于其他组（p = 0.016）。
少量的CAG重复与较高的前列腺重量相关。雄激素受体的CAG重复平均次数和CYP17基因的A2A2变体与较大的基质表面积相关。
