Iwabuchi Junshin, Wako Syun, Tanaka Tatsuya, Ishikawa Azusa, Yoshida Yuki, Miyata Shohei
Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):149-55. doi: 10.1016/j.jsbmb.2007.01.007. Epub 2007 Jun 22.
Analysis of 5'-RACE clones revealed two Cyp19 transcript variants (gonad p450 aroms 1 and 2) in the gonads and one Cyp transcript (brain p450 arom) in the brain that differed in their 5'-untranslated region (UTR). Since all cDNAs contained an identical open reading frame, it is considered that while Xenopus aromatase may be encoded by a single Cyp19 gene, it is transcribed by tissue-specific promoters, each of which may be regulated by a distinct set of transcriptional factors. While gonad p450 aroms 1 and 2 and brain p450 arom were expressed in the gonads, brain p450 arom was the predominantly expressed aromatase gene in the brain, with a low expression level of gonad p450 arom 1.
