Plavsić Z, Popovac D, Mandić D
Gradski zavod za bolesti pluća i zaśtitu od tuberkuloze Beograd.
Plucne Bolesti. 1991 Jan-Jun;43(1-2):21-5.
The control of symptoms in patients with allergic rhinitis and bronchial asthma can not be always attained with hyposensitization. This may be achieved with more success with additional treatment with H1 antagonists of histamine receptors. By hyposensitization statistically significant decrease of the total IgE was achieved. Contrary to this, in cases in which the symptoms could not be controlled with hyposensitization, only antihistamines were additionally administered, no significant decrease of IgE took place. These were, probably, more severe cases in which the symptoms could not be controlled with the hyposensitization only. No significant effect on the values of blood eosinophiles was registered with hyposensitization or additional administration of antihistamines.
变应性鼻炎和支气管哮喘患者的症状并非总能通过减敏疗法得到控制。联合使用组胺H1受体拮抗剂进行额外治疗可能会更成功地实现症状控制。通过减敏疗法，总IgE在统计学上显著降低。与此相反，在那些减敏疗法无法控制症状的病例中，仅额外给予抗组胺药，IgE并未显著降低。这些可能是仅靠减敏疗法无法控制症状的更严重病例。减敏疗法或额外给予抗组胺药对血液嗜酸性粒细胞值均无显著影响。
