Paranos S, Despotović N, Vidanović M, Bojović I, Milovanović M, Dmitrović V
Klinicko-bolnicki centar "Zvezdara", Klinicki institut za alergologiju i klinicku imunologiju, Beograd.
Plucne Bolesti. 1991 Jan-Jun;43(1-2):89-93.
The study was performed in 20 patients with mild and moderately severe forms of bronchial asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and ranitidine was used in the first group of patients (7 females and 3 males, mean years of age 37.9). Dosage of theophylline from patients' sera was monitored prior and at 3, 6, and 12 hours beginning with the initial morning dose. The second group of patients (9 females and 1 male, mean age 46.3 years) were on ranitidine therapy along with 250 mg intravenous theophylline-ethylene-diamine. Fractionated dosage of theophylline was made within 12 hours. Pharmacokinetic parameters were calculated according to the concentration of theophylline in the sera of patients in the second group. In the sera of patients in the first group significantly higher concentrations of theophylline were found at 3 and 6 hour of the initial morning dose (p less than 0.05). In the second group a significant difference was not registered for the assessed pharmacokinetic parameters. This investigation indicates that there are individual differences of the metabolism of theophylline drugs with concommitant use of ranitidine.
该研究对20例患有轻度和中度严重形式的支气管哮喘或慢性阻塞性支气管炎的患者进行。第一组患者（7名女性和3名男性，平均年龄37.9岁）使用口服茶碱（缓释剂型）和雷尼替丁。从初始晨剂量开始，在给药前以及给药后3、6和12小时监测患者血清中茶碱的剂量。第二组患者（9名女性和1名男性，平均年龄46.3岁）接受雷尼替丁治疗，并同时静脉注射250毫克氨茶碱-乙二胺。在12小时内分剂量给予茶碱。根据第二组患者血清中茶碱的浓度计算药代动力学参数。在第一组患者血清中，初始晨剂量后3小时和6小时的茶碱浓度显著更高（p小于0.05）。在第二组中，评估的药代动力学参数未发现显著差异。该研究表明，同时使用雷尼替丁时，茶碱类药物的代谢存在个体差异。
