Paranos S, Despotović N, Vidanović M, Bojović I, Milovanović M, Dmitrović V, Bozović M
Glas Srp Akad Nauka Med. 1991(41):45-52.
Investigations were performed on 20 patients with mild and moderately severe forms of bronchiale asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and Ranitidine (second generation H2-blocker) were used in the first group of patients (7 females and 3 males, average age 37.9). Dosage of theophylline from patients sera was monitored at 3, 6 and 12 hours, beginning with the initial morning dose. The second group of patients (9 females and 1 male, average age 46.3) were on Ranitidine therapy, along with 250 mg intravenous theophylline-ethylene-diamine. Fractionated dosage of theophylline was done within 12 hours. Pharmacokinetic parameters were calculated according to the concentration of theophylline in the sera of patients in the second group. Significant differences were not found by statistical analysis (T-test) in the pharmacokinetic parameters of theophylline although significantly higher concentrations of theophylline were found in the sera of patients in the first group. This indicated that there are individual differences on the metabolism of theophylline drugs with concomitant use of Ranitidine.
对20例轻度至中度支气管哮喘或慢性阻塞性支气管炎患者进行了研究。第一组患者（7名女性和3名男性，平均年龄37.9岁）使用口服茶碱（缓释剂型）和雷尼替丁（第二代H2受体阻滞剂）。从早晨首次给药开始，在3、6和12小时监测患者血清中的茶碱剂量。第二组患者（9名女性和1名男性，平均年龄46.3岁）接受雷尼替丁治疗，同时静脉注射250毫克氨茶碱-乙二胺。在12小时内分剂量给予茶碱。根据第二组患者血清中茶碱的浓度计算药代动力学参数。尽管第一组患者血清中的茶碱浓度明显更高，但通过统计学分析（t检验）未发现茶碱药代动力学参数存在显著差异。这表明在同时使用雷尼替丁的情况下，茶碱药物的代谢存在个体差异。
