Dalla Palma L, Pozzi-Mucelli R, Cova M, Iannis M R, Pagnan L
Istituto di Radiologia, Università, Trieste.
Radiol Med. 1991 Oct;82(4):393-400.
To determine the contribution of Gd-DTPA to the evaluation of vertebral infections 16 MR examinations with i.v. Gd-DTPA injection were performed on 12 patients with diagnosis of spondylodiscitis. All patients were examined with both SE T1- and SE T2-weighted sequences. The SE T1-weighted sequence was repeated following i.v. Gd-DTPA injection (0.1 nmol/kg). Signal intensities and visibility of the lesions were evaluated with MR. For each lesion the grade of visibility on SE T1-weighted sequence was compared with the grade of visibility on SE T2-weighted sequence. Moreover, for each study the information obtained by the combined evaluation of SE T1-weighted sequence without and with Gd-DTPA was compared with the information obtained by combined SE T1- and SE T2-weighted sequences. Gd-DTPA was useful in the evaluation of lesions of the discal space, showing in all cases an area of low signal intensity with peripheral enhancement; this finding allowed, in some cases, to differentiate mild spondylodiscitis from degenerative features. Gd-DTPA was also very useful in determining the extent of the disease: in comparison with MR study without contrast media, the combined evaluation of SE T1-weighted sequence without and with Gd-DTPA better showed the extent of the disease in 7/8 cases (88%).
为确定钆喷酸葡胺(Gd-DTPA)在评估椎体感染中的作用,对12例诊断为脊椎椎间盘炎的患者进行了16次静脉注射Gd-DTPA后的磁共振成像(MR)检查。所有患者均接受了自旋回波(SE)T1加权序列和SE T2加权序列检查。静脉注射Gd-DTPA(0.1 nmol/kg)后重复SE T1加权序列检查。通过MR评估病变的信号强度和可视性。对于每个病变,比较SE T1加权序列上的可视等级与SE T2加权序列上的可视等级。此外,对于每项研究,将未注射和注射Gd-DTPA的SE T1加权序列联合评估所获得的信息与SE T1加权序列和SE T2加权序列联合评估所获得的信息进行比较。Gd-DTPA在评估椎间盘间隙病变方面很有用,在所有病例中均显示出低信号强度区域伴有周边强化;这一发现使得在某些情况下能够将轻度脊椎椎间盘炎与退行性病变区分开来。Gd-DTPA在确定疾病范围方面也非常有用:与未使用造影剂的MR研究相比,未注射和注射Gd-DTPA的SE T1加权序列联合评估在7/8例(88%)病例中能更好地显示疾病范围。