Al-Rashidi Faleh, Bhat Misha, Pierre Leif, Koul Bansi
Cardiothoracic Surgery, University Hospital Lund, 221 85 Lund, Sweden.
Interact Cardiovasc Thorac Surg. 2007 Oct;6(5):618-22. doi: 10.1510/icvts.2007.155523. Epub 2007 Jul 25.
The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at admission and discharge were statistically similar in both groups. The total blood product transfusion requirements were significantly reduced in the plateletpheresis group compared with the control group (3.2 units and 5.1 units, respectively, P=0.036). The total blood donor exposure was also reduced significantly in the plateletpheresis group compared with the control group (3.2 and 6.9 donors/patient, respectively, P<0.001). The direct costs for the hospital for the plateletpheresis procedure, including costs for all blood products, were similar to those for blood products alone in the control group. In summary, acute plateletpheresis in combination with low-dose aprotinin significantly reduces the blood product transfusions and blood donor exposures following the Ross operation; the treatment is cost-effective.
对18例接受择期罗斯手术的年轻成年患者，研究了急性术中血小板单采术（血小板回收率25%）联合术中低剂量抑肽酶（200万单位）对血液保护的效果。将结果与19例未进行血小板单采术的类似患者组成的对照组进行比较。两组入院时和出院时的血液学及凝血参数在统计学上相似。与对照组相比，血小板单采术组的血液制品总输注需求量显著降低（分别为3.2单位和5.1单位，P = 0.036）。与对照组相比，血小板单采术组的总献血者暴露量也显著降低（分别为3.2名和6.9名献血者/患者，P < 0.001）。包括所有血液制品费用在内的血小板单采术医院直接成本与对照组仅血液制品的成本相似。总之，急性血小板单采术联合低剂量抑肽酶可显著减少罗斯手术后的血液制品输注和献血者暴露；该治疗具有成本效益。
