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缺血性心肌病冠状动脉搭桥术后的逆向重塑:通过延迟强化磁共振成像评估心肌存活情况可为心脏外科医生提供帮助。

Reverse-remodeling after coronary artery bypass grafting in ischemic cardiomyopathy: assessment of myocardial viability by delayed-enhanced magnetic resonance imaging can help cardiac surgeons.

作者信息

Ogawa Mitsugu, Doi Kiyoshi, Fukumoto Atsushi, Yaku Hitoshi

机构信息

Department of Cardiovascular and Thoracic Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho Kawaramachi-Hirokoji Kamigyo-ku, Kyoto 602-8566, Japan.

出版信息

Interact Cardiovasc Thorac Surg. 2007 Oct;6(5):673-5. doi: 10.1510/icvts.2007.155275. Epub 2007 Jul 26.

Abstract

Preoperative delayed-enhanced magnetic resonance imaging (DE-MRI) was performed to estimate myocardial viability in a 57-year-old man with ischemic cardiomyopathy in order to decide the best course of treatment. The patient was diagnosed as having congestive heart failure with triple-vessel involvement (ejection fraction of 7%, end-diastolic volume index of 160 ml/m2, end-systolic volume index of 148 ml/m2). 99mTc-sestamibi single-photon emission computed tomography revealed severe reduction of the uptake at both stress and resting phases in the anterior, lateral and inferior segments. However, DE-MRI demonstrated transmural hyperenhancement to be <25% within the whole ventricular wall, implying that, though there was extensive subendoventricular myocardial infarction, there was substantial viable myocardium. Therefore, with the expectation that functional recovery was possible with coronary revascularization alone, we performed a complete revascularization with off-pump coronary artery bypass grafting. Six months after the operation, catheterization demonstrated dramatic improvement in ventricular function, with the ejection fraction having increased to 36%. This case suggests that preoperative assessment of myocardial viability by DE-MRI could help cardiac surgeons to choose the best treatment for patients with ischemic cardiomyopathy.

摘要

对一名57岁缺血性心肌病男性患者进行术前延迟增强磁共振成像(DE-MRI)以评估心肌活力,从而确定最佳治疗方案。该患者被诊断为充血性心力衰竭,三支血管受累(射血分数为7%,舒张末期容积指数为160 ml/m²,收缩末期容积指数为148 ml/m²)。99mTc-甲氧基异丁基异腈单光子发射计算机断层扫描显示前壁、侧壁和下壁在负荷期和静息期的摄取均严重降低。然而,DE-MRI显示整个心室壁透壁性强化<25%,这意味着尽管存在广泛的心内膜下心肌梗死,但仍有大量存活心肌。因此,鉴于期望仅通过冠状动脉血运重建就能实现功能恢复,我们采用非体外循环冠状动脉旁路移植术进行了完全血运重建。术后6个月,心导管检查显示心室功能显著改善,射血分数增至36%。该病例表明,术前通过DE-MRI评估心肌活力有助于心脏外科医生为缺血性心肌病患者选择最佳治疗方案。

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