Carstensen Steen, Nelson Greg C I, Hansen Peter S, Macken Lewis, Irons Stephen, Flynn Michael, Kovoor Pramesh, Soo Hoo Soon Y, Ward Michael R, Rasmussen Helge H
Department of Cardiology, Royal North Shore Hospital, University of Sydney, Australia.
Eur Heart J. 2007 Oct;28(19):2313-9. doi: 10.1093/eurheartj/ehm306. Epub 2007 Aug 1.
We investigated the net benefit in the outcome of reducing treatment delay through field triage and emergency department (ED) bypass in patients with ST-elevation myocardial infarction (STEMI) treated with primary angioplasty.
In a prospective registry study, consecutive patients with suspected STEMI were assigned to: (i) pre-hospital ECG and triage or (ii) ECG and triage at the closest ED, solely based on ambulance availability. Four district hospitals and one regional heart centre serviced the 890,000 population metropolitan area and primary angioplasty was the only reperfusion strategy employed. Baseline characteristics were similar in STEMI patients triaged in the field (108) and the EDs (193). Symptom onset to balloon times: 154 [inter-quartile range (IQR) 120-233) vs. 249 (IQR 184-405) min (P<0.001) and peak creatine kinase in early presenters (<2 h): 1435 (95 %CI: 904-1966) U/L vs. 2320 (95% CI: 1881-2762) U/L (P=0.009) were lower in field- than in ED-triaged patients. Mortality in the PCI treated were 1.1 and 8.2% [P=0.025, RR 0.14 (95% CI: 0.01-1.08)] and overall mortality were 1.9 and 7.3% [P=0.046, RR 0.26 (95% CI: 0.05-1.11)].
Field-triage and ED bypass were feasible means of reducing treatment delay in patients with suspected STEMI and resulted in smaller infarct size in early presenters and a trend towards a reduction in mortality.
我们研究了对于接受直接血管成形术治疗的ST段抬高型心肌梗死(STEMI)患者,通过现场分诊和绕过急诊科(ED)来减少治疗延迟所带来的净效益。
在一项前瞻性登记研究中,连续的疑似STEMI患者被分配至:(i)院前心电图及分诊组,或(ii)仅根据救护车可用性在距离最近的急诊科进行心电图及分诊组。四家地区医院和一家区域心脏中心为一个拥有89万人口的大都市地区提供服务,直接血管成形术是唯一采用的再灌注策略。在现场分诊的STEMI患者(108例)和急诊科分诊的患者(193例)中,基线特征相似。症状发作至球囊扩张时间:154 [四分位间距(IQR)120 - 233] 分钟 vs. 249(IQR 184 - 405)分钟(P<0.001),早期就诊者(<2小时)的肌酸激酶峰值:1435(95%CI:904 - 1966)U/L vs. 2320(95%CI:1881 - 2762)U/L(P = 0.009),现场分诊患者低于急诊科分诊患者。接受PCI治疗患者的死亡率分别为1.1%和8.2% [P = 0.025,RR 0.14(95%CI:0.01 - 1.08)],总体死亡率分别为1.9%和7.3% [P = 0.046,RR 0.26(95%CI:0.05 - 1.11)]。
现场分诊和绕过急诊科是减少疑似STEMI患者治疗延迟的可行方法,并且使早期就诊者的梗死面积更小,还有降低死亡率的趋势。