Calin George A, Croce Carlo M
Department of Molecular Virology, Immunology and Medical Genetics, Colleges of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.
J Clin Invest. 2007 Aug;117(8):2059-66. doi: 10.1172/JCI32577.
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
在癌细胞中,成熟和/或前体微小RNA存在广泛的异常表达,因为微小RNA会因染色体改变和其他基因组异常而失调。识别此类异常具有明确的诊断和预后意义,而且越来越多的例子表明某些人类癌症与微小RNA基因座的修饰之间存在联系。