van Zwieten P A
J Pharm Pharmacol. 1977 Apr;29(4):229-34. doi: 10.1111/j.2042-7158.1977.tb11294.x.
The central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethylperazine, thioridazine), by chlorprothixene and to a limited extent by haloperidol administered via the same route. Pimozide and some benzodiazepines (chlordiazepoxide, diazepam and flurazepam) hardly influenced the central hypotensive response to clonidine. The antagonism between clonidine and the psychotropic drugs is probably associated with central alpha-adrenoceptors, clonidine being the agonist and the neuroleptic agents the antagonists at these receptors. Virtually the same type of antagonism was observed in conscious, spontaneously hypertensive rats where both clonidine and the neuroleptic drugs were injected intravenously. The phenothiazines and also piperoxane effectively diminished the centrally induced hypotensive response to clonidine, whereas the initial pressor effect to clonidine was not reduced.
将可乐定注入氯醛糖麻醉猫的椎动脉所产生的中枢性降压作用，可被几种吩噻嗪类抗精神病药物（氯丙嗪、丙嗪、异丙嗪、硫乙拉嗪、甲硫达嗪）、氯普噻吨拮抗，通过相同途径给药的氟哌啶醇在一定程度上也可拮抗。匹莫齐特和一些苯二氮䓬类药物（氯氮卓、地西泮和氟西泮）几乎不影响对可乐定的中枢性降压反应。可乐定与这些精神药物之间的拮抗作用可能与中枢α-肾上腺素能受体有关，可乐定是这些受体的激动剂，而抗精神病药物是拮抗剂。在清醒的自发性高血压大鼠中静脉注射可乐定和抗精神病药物时，观察到几乎相同类型的拮抗作用。吩噻嗪类药物以及哌罗克生可有效减弱对可乐定的中枢性诱导降压反应，而对可乐定的初始升压作用则未减弱。
