van Zwieten P A
Pharmacology. 1977;15(4):331-6. doi: 10.1159/000136707.
Trazodone, a non-tricyclic drug with antidepressant properties, diminished the central hypotensive response to clonidine in a dose-dependent manner. Both drugs were infused into the left vertebral artery of chloralose-anaesthetized cats. Intravenously injected trazodone did not reduce the central hypotensive effect of clonidine. The antagonism probably occurs at the level of central alpha-adrenoreceptors in the brain stem, where clonidine is the alpha-agonist and trazodone the alpha-antagonist. Such an antagonism, already known for clonidine and the tricyclic drugs also holds for non-tricyclic antidepressants, provided that they possess alpha-adrenoreceptor-blocking activity.
曲唑酮是一种具有抗抑郁特性的非三环类药物，它能以剂量依赖的方式减弱对可乐定的中枢性降压反应。两种药物均注入氯醛糖麻醉猫的左椎动脉。静脉注射曲唑酮不会降低可乐定的中枢性降压作用。这种拮抗作用可能发生在脑干的中枢α-肾上腺素能受体水平，其中可乐定是α-激动剂，曲唑酮是α-拮抗剂。这种可乐定与三环类药物之间已知的拮抗作用，对于非三环类抗抑郁药也同样适用，前提是它们具有α-肾上腺素能受体阻断活性。
