Colinas Pedro A, Bravo Rodolfo D
LADECOR, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900 La Plata, Argentina.
Carbohydr Res. 2007 Nov 5;342(15):2297-302. doi: 10.1016/j.carres.2007.06.027. Epub 2007 Jul 13.
A series of novel N-glycosyl sulfonamides were prepared via Ferrier sulfonamidoglycosylation of D-glycals with good to high alpha-stereoselectivity. Two new glycosylsulfamides were tested as carbonic anhydrase (CA II) inhibitors and showed good properties in the micromolar range.
通过D-甘醇的费里尔磺酰胺基糖基化反应制备了一系列具有良好至高α-立体选择性的新型N-糖基磺酰胺。测试了两种新的糖基磺酰胺作为碳酸酐酶（CA II）抑制剂，在微摩尔范围内表现出良好的性能。
