Belogolovkin Victoria, Eddleman Keith A, Malone Fergal D, Sullivan Lisa, Ball Robert H, Nyberg David A, Comstock Christine H, Hankins Gary D V, Carter Suzanne, Dugoff Lorraine, Craigo Sabrina D, Timor-Tritsch Ilan E, Carr Stephen R, Wolfe Honor M, D'Alton Mary E
Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
J Matern Fetal Neonatal Med. 2007 Jul;20(7):509-13. doi: 10.1080/14767050701420027.
To evaluate the relationship between low maternal body mass index (BMI) as calculated in the first trimester and the risk of preeclampsia and gestational hypertension.
Patients enrolled in the First And Second Trimester Evaluation of Risk for aneuploidy (FASTER) trial were grouped into three weight categories: low BMI (BMI <19.8 kg/m2), normal BMI (BMI 19.8 - 26 kg/m2), and overweight BMI (26.1 - 29 kg/m2). The incidences of gestational hypertension and preeclampsia were ascertained for each group. Tests for differences in crude incidence proportions were performed using Chi-square tests. Multiple logistic regression was used to adjust for maternal age, race, parity, obesity, use of assisted reproductive technology (ART), in vitro fertilization (IVF), gestational diabetes, pre-gestational diabetes, cocaine use, and smoking.
The proportion of patients having gestational hypertension in the low BMI group was 2.0% compared to 3.2% for normal BMI and 6.0% for overweight BMI (p < 0.0001). Women with low BMI were also less likely to develop preeclampsia, 1.1% vs. 1.9% for normal BMI and 2.8% for overweight BMI (p < 0.0001).
We found that women with low BMI in the first trimester were significantly less likely to develop gestational hypertension or preeclampsia than women with a normal BMI.
评估孕早期计算得出的低母体体重指数（BMI）与子痫前期及妊娠期高血压风险之间的关系。
参加孕早期和孕中期非整倍体风险评估（FASTER）试验的患者被分为三个体重类别：低BMI（BMI<19.8kg/m²）、正常BMI（BMI 19.8 - 26kg/m²）和超重BMI（26.1 - 29kg/m²）。确定每组妊娠期高血压和子痫前期的发病率。使用卡方检验对粗发病率比例的差异进行检验。采用多因素逻辑回归分析来调整母体年龄、种族、产次、肥胖、辅助生殖技术（ART）的使用、体外受精（IVF）、妊娠期糖尿病、孕前糖尿病、可卡因使用和吸烟等因素。
低BMI组妊娠期高血压患者的比例为2.0%，正常BMI组为3.2%，超重BMI组为6.0%（p<0.0001）。低BMI的女性患子痫前期的可能性也较小，分别为1.1%、正常BMI组为1.9%、超重BMI组为2.8%（p<0.0001）。
我们发现，孕早期BMI低的女性比BMI正常的女性患妊娠期高血压或子痫前期的可能性显著降低。
