Novak Gregg, Kross Kimberly, Follmer Kristy, Brofferio Alessandra, Shirani Jamshid
General Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822-2160, USA.
Clin Cardiol. 2007 Jul;30(7):355-8. doi: 10.1002/clc.20065.
Transient left ventricular (LV) apical ballooning and normal epicardial coronary arteries are the hallmarks of Takotsubo cardiomyopathy. The syndrome is often triggered by emotional or physiologic stress, and its pathogenesis is poorly understood. Current proposals focus on elevated cathecolamines in association with abnormal coronary artery endothelium, coronary microcirculation or LV geometry. Right ventricular (RV) involvement, as described in our patient, is not reported as a typical feature. Presence of RV dysfunction may affect the initial management of these patients and raises questions regarding the universal applicability of the currently proposed pathophysiologic mechanisms of this syndrome.
短暂性左心室心尖部气球样变和心外膜冠状动脉正常是应激性心肌病的特征。该综合征常由情绪或生理应激触发，其发病机制尚不清楚。目前的观点集中在儿茶酚胺升高与冠状动脉内皮异常、冠状动脉微循环或左心室几何形状异常有关。如我们患者中所描述的右心室受累情况，并未被报道为典型特征。右心室功能障碍的存在可能会影响这些患者的初始治疗，并对目前所提出的该综合征病理生理机制的普遍适用性提出质疑。
