鉴定用于早期检测胰腺肿瘤的分子标志物。
Identifying molecular markers for the early detection of pancreatic neoplasia.
作者信息
Goggins Michael
机构信息
Department of Pathology, Medicine, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
出版信息
Semin Oncol. 2007 Aug;34(4):303-10. doi: 10.1053/j.seminoncol.2007.05.003.
Abstract
Pancreatic cancer is the fourth most common cause of cancer death in the United States. There is a great need for better diagnostic markers of pancreatic neoplasia. Better markers would improve the early diagnosis of pancreatic cancer and allow more patients to undergo curative surgical resection. Identifying individuals at high risk of developing pancreatic cancer and applying markers that could identify precancerous lesions of the pancreas in these individuals could allow such lesions to be resected before the development of pancreatic cancer. As we continue to characterize the genetic, epigenetic, and proteomics alterations that occur in pancreatic cancers and their percursors, better diagnostic markers of pancreatic cancer are expected to follow.
摘要
胰腺癌是美国癌症死亡的第四大常见原因。对更好的胰腺肿瘤诊断标志物有很大需求。更好的标志物将改善胰腺癌的早期诊断，并使更多患者能够接受根治性手术切除。识别有患胰腺癌高风险的个体，并应用能够识别这些个体胰腺癌前病变的标志物，可使这些病变在胰腺癌发生之前就被切除。随着我们继续描述胰腺癌及其前驱病变中发生的基因、表观遗传和蛋白质组学改变，有望出现更好的胰腺癌诊断标志物。
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