Lorand-Metze I, Califani S M V, Ribeiro E, Lima C S P, Metze K
Faculty of Medicine, State University of Campinas, Brazil.
Leuk Res. 2008 Feb;32(2):211-3. doi: 10.1016/j.leukres.2007.06.014. Epub 2007 Aug 6.
Several phenotypic abnormalities of bone marrow (BM) hemopoietic precursors have been associated with disease progression in myelodysplastic syndromes (MDS). We analyzed the influence on overall survival of the expression of lineage and maturation-associated antigens of BM hemopoietic cells quantified in a previous study. In the univariate Cox regression the peripheral platelet count was a significant favourable factor for overall survival. Unfavorable prognostic factors were: WPSS, increase in BM CD34+ cells, increased mean fluorescence intensity (MFI) of CD13 on myelocytes, metamyelocytes and mature neutrophils as well as increased CD45 of myelocytes and mature neutrophils. In a model containing platelet count, WPSS and MFI of CD45 and CD13 on mature neutrophils, only hyperexpression of CD13 and degree of thrombocytopenia were independent risk factors. Therefore, phenotypic features that can also be obtained from PB might be useful for predicting survival in MDS.
骨髓（BM）造血前体细胞的几种表型异常与骨髓增生异常综合征（MDS）的疾病进展相关。我们分析了先前研究中量化的BM造血细胞谱系和成熟相关抗原表达对总生存期的影响。在单变量Cox回归中，外周血小板计数是总生存期的一个显著有利因素。不良预后因素包括：世界预后评分系统（WPSS）、BM中CD34+细胞增加、中幼粒细胞、晚幼粒细胞和成熟中性粒细胞上CD13平均荧光强度（MFI）增加以及中幼粒细胞和成熟中性粒细胞CD45增加。在一个包含血小板计数、WPSS以及成熟中性粒细胞上CD45和CD13的MFI的模型中，只有CD13的过表达和血小板减少程度是独立危险因素。因此，也可从外周血（PB）获得的表型特征可能有助于预测MDS的生存期。
