Bojarska-Junak Agnieszka, Hus Iwona, Szczepanek Ewa Wasik, Dmoszyńska Anna, Roliński Jacek
Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland.
Leuk Res. 2008 Feb;32(2):225-33. doi: 10.1016/j.leukres.2007.06.007. Epub 2007 Aug 1.
The aim of the study was to evaluate TNF and TNF receptor levels in peripheral blood (PB) and bone marrow (BM) in correlation with clinical and laboratory parameters of B-CLL patients. TNF concentration was significantly higher in BM than in PB. In B-CLL patients elevated TNF and sTNF-RII plasma levels had a high correlation with adverse prognostic factors such as ZAP-70 and CD38. Moreover, the percentage of TNF-producing T cells was significantly higher in ZAP-70-positive comparing to ZAP-70-negative patients. TNF and sTNF-RII plasma levels were higher in the group of patients requiring treatment comparing to the patients who did not.
该研究的目的是评估B淋巴细胞慢性淋巴细胞白血病（B-CLL）患者外周血（PB）和骨髓（BM）中的肿瘤坏死因子（TNF）及TNF受体水平，并将其与临床和实验室参数进行关联分析。骨髓中的TNF浓度显著高于外周血。在B-CLL患者中，TNF和可溶性TNF受体II（sTNF-RII）血浆水平升高与诸如ZAP-70和CD38等不良预后因素高度相关。此外，与ZAP-70阴性患者相比，ZAP-70阳性患者中产生TNF的T细胞百分比显著更高。与无需治疗的患者相比，需要治疗的患者组中TNF和sTNF-RII血浆水平更高。
