Gonçalves Paula P, Silva Virgília S
Departamento de Biologia, Campus Universitário de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
J Inorg Biochem. 2007 Sep;101(9):1291-338. doi: 10.1016/j.jinorgbio.2007.06.002. Epub 2007 Jun 12.
Neurobehavioral disorders, except their most overt form, tend to lie beyond the reach of clinicians. Presently, the use of molecular data in the decision-making processes is limited. However, as details of the mechanisms of neurotoxic action of aluminium become clearer, a more complete picture of possible molecular targets of aluminium can be anticipated, which promises better prediction of the neurotoxicological potential of aluminium exposure. In practical terms, a critical analysis of current data on the effects of aluminium on neurotransmission can be of great benefit due to the rapidly expanding knowledge of the neurotoxicological potential of aluminium. This review concludes that impairment of neurotransmission is a strong predictor of outcome in neurobehavioral disorders. Key questions and challenges for future research into aluminium neurotoxicity are also identified.
神经行为障碍，除了其最明显的形式外，往往超出临床医生的能力范围。目前，分子数据在决策过程中的应用有限。然而，随着铝的神经毒性作用机制的细节越来越清晰，可以预期对铝可能的分子靶点会有更全面的了解，这有望更好地预测铝暴露的神经毒理学潜力。实际上，鉴于对铝的神经毒理学潜力的认识迅速扩大，对当前关于铝对神经传递影响的数据进行批判性分析可能会有很大益处。本综述得出结论，神经传递受损是神经行为障碍预后的有力预测指标。还确定了未来铝神经毒性研究的关键问题和挑战。
