Bodeau-Livinec Florence, Surman Geraldine, Kaminski Monique, Wilkinson Andrew R, Ancel Pierre-Yves, Kurinczuk Jennifer J
National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.
Arch Dis Child. 2007 Dec;92(12):1099-104. doi: 10.1136/adc.2007.117416. Epub 2007 Aug 3.
To study recent trends in the cumulative incidence of visual impairment in childhood over a 15-year period and to assess progress against WHO goals for prevention.
DESIGN, SETTING AND PARTICIPANTS: Data from a population-based register of visual impairment in southern England were used to estimate cumulative incidence and trends in visual impairment (VI) and severe visual impairment/blindness (SVI/BL) for children born in 1984-1998. Causes were classified by anatomical site(s), timing of insult(s) and whether the visual impairment was potentially preventable or treatable.
Of 691 eligible children, 358 (53%) had VI and 323 (47%) SVI/BL. The cumulative incidence of VI to age 12 years was 7.1 (95% CI 6.4 to 7.8) per 10,000 live births and for SVI/BL was 6.2 (95% CI 5.6 to 6.9); the incidence of both decreased significantly over time. There was an inverse relationship with gestational age and birth weight, although the risk of visual impairment associated with prematurity and low birth weight decreased substantially over time. 55% of children with VI and 77% with SVI/BL had other impairments; the proportion of associated impairments among children with VI decreased over time. 130 (19%) of the children have died, with over half dying before the age of 5.
There is evidence of a temporal decline in the incidence of VI and SVI/BL in births from 1984 to 1998 especially in very preterm and low birthweight infants. Early childhood mortality was high. The causes of visual impairment in UK children are numerous, complex and often part of a wider picture of childhood disability.
研究15年间儿童视力损害累积发病率的近期趋势,并评估在实现世界卫生组织预防目标方面取得的进展。
设计、背景和参与者:利用英格兰南部基于人群的视力损害登记数据,估算1984 - 1998年出生儿童的视力损害(VI)和严重视力损害/失明(SVI/BL)的累积发病率及趋势。病因按解剖部位、损伤时间以及视力损害是否可预防或可治疗进行分类。
在691名符合条件的儿童中,358名(53%)有视力损害,323名(47%)有严重视力损害/失明。12岁时视力损害的累积发病率为每10000例活产7.1(95%可信区间6.4至7.8),严重视力损害/失明为6.2(95%可信区间5.6至6.9);两者的发病率均随时间显著下降。发病率与胎龄和出生体重呈负相关,尽管与早产和低出生体重相关的视力损害风险随时间大幅下降。55%的视力损害儿童和77%的严重视力损害/失明儿童有其他损伤;视力损害儿童中相关损伤的比例随时间下降。130名(19%)儿童已死亡,其中一半以上在5岁前死亡。
有证据表明,1984年至1998年出生儿童中视力损害和严重视力损害/失明的发病率呈时间下降趋势,尤其是在极早产和低出生体重婴儿中。幼儿死亡率很高。英国儿童视力损害的病因众多、复杂,且往往是儿童残疾更广泛情况的一部分。