Sainz M, García-Valdecasas J, Garófano M, Ballesteros J M
Hospital Clinico S. Cecilio, Granada, Spain.
Audiol Neurootol. 2007;12(6):401-6. doi: 10.1159/000106773. Epub 2007 Aug 3.
Constant histological changes in otosclerosis lead to progressive hearing loss which may end up in a profound hearing loss and then be treated by means of cochlear implants. These progressive changes could be followed by changes in cochlear implants fitting and speech discrimination results over the years.
The aim of the study is to correlate the progressive histological changes to the cochlear implant clinical outcomes (fitting and speech discrimination results). Also main complications (facial nerve stimulation and difficulties at insertion) and new complications will be discussed.
A 5-year prospective case-control study was performed in order to compare cochlear implant results in otosclerosis patients to those in a matched-pair control group.
Fifteen otosclerosis patients were followed throughout the study. Preoperatively temporal bone high-resolution computed tomography, electrically evoked auditory brainstem responses and speech discrimination tests were performed in order to select the patients to be implanted.
Not only difficulties with electrode guide insertion were reported, but also difficulties with fitting over the years, due to increasing difficulties to spread the electrical stimuli, which provokes increasing thresholds, maximum comfort levels and charges needed to stimulate hearing cells in basal and medial turn electrodes (p < 0.05), which required deactivating some basal and medial turn electrodes in order to improve cochlear implant effectiveness. The results demonstrated no statistical differences in speech discrimination in otosclerosis patients compared to the control group (p > 0.05). Several complications were reported: facial nerve stimulation (7.14%) and sudden episodes of tinnitus and headaches (14.28%).
Although progressive histological changes in otosclerosis lead to increasing thresholds, maximum comfort levels and charges needed to stimulate hearing cells, speech discrimination results support the cochlear implantation in otosclerosis.
耳硬化症中持续的组织学变化会导致渐进性听力损失,最终可能发展为重度听力损失,进而需通过人工耳蜗植入进行治疗。随着时间的推移,这些渐进性变化可能会导致人工耳蜗适配情况及言语识别结果发生改变。
本研究旨在将渐进性组织学变化与人工耳蜗临床效果(适配情况及言语识别结果)相关联。同时,还将讨论主要并发症(面神经刺激和植入困难)以及新出现的并发症。
开展了一项为期5年的前瞻性病例对照研究,以比较耳硬化症患者与配对对照组的人工耳蜗植入效果。
在整个研究过程中对15例耳硬化症患者进行了随访。术前进行了颞骨高分辨率计算机断层扫描、电诱发听觉脑干反应和言语识别测试,以选择适合植入的患者。
研究不仅报告了电极引导插入困难,还发现随着时间推移存在适配困难,原因是电刺激扩散难度增加,这导致刺激基底和中圈电极中的听觉细胞所需的阈值、最大舒适水平和电荷量增加(p < 0.05),为提高人工耳蜗效果,需要停用一些基底和中圈电极。结果表明,与对照组相比,耳硬化症患者的言语识别没有统计学差异(p > 0.05)。报告了几种并发症:面神经刺激(7.14%)以及耳鸣和头痛突发情况(14.28%)。
尽管耳硬化症中的渐进性组织学变化会导致刺激听觉细胞所需的阈值、最大舒适水平和电荷量增加,但言语识别结果支持对耳硬化症患者进行人工耳蜗植入。