Schröder R, Bien K, Kott R, Meyers I, Vössing R
Institut für Pathologie, Universität Köln, Federal Republic of Germany.
Acta Neuropathol. 1991;82(5):389-94. doi: 10.1007/BF00296550.
The monoclonal antibody (mAb) Ki-67 is a marker for the growth fraction (GF) of tumor cells. The exact relationship between the Ki-67 labeling index (LI) and the conventional diagnostic criterion of the proliferative activity of brain tumors, the mitotic index (MI), is unknown except for some general references. On serial frozen sections Ki-67 LI and MI were determined in nearly identical areas of 32 glioblastomas, 20 grade III astrocytomas, 21 grade II astrocytomas and 20 selected cases of meningioma. The data not only clearly showed different median values of LI and MI for the various malignancy grades, but also similar regression coefficients for each glioma type. A non-linear relationship between the two indices was found for all glioma cases with high significance and high correlation coefficient; (LI) = 5.6 (MI)0.59. This results from differing intermitotic cycle times, the variability of which can be estimated from the data given.
单克隆抗体（mAb）Ki-67是肿瘤细胞生长分数（GF）的标志物。除了一些一般性参考资料外，Ki-67标记指数（LI）与脑肿瘤增殖活性的传统诊断标准——有丝分裂指数（MI）之间的确切关系尚不清楚。在32例胶质母细胞瘤、20例III级星形细胞瘤、21例II级星形细胞瘤和20例选定的脑膜瘤病例的连续冰冻切片上，在几乎相同的区域测定了Ki-67 LI和MI。数据不仅清楚地显示了不同恶性程度的LI和MI的中位数，而且每种胶质瘤类型的回归系数也相似。在所有胶质瘤病例中发现这两个指数之间存在非线性关系，具有高度显著性和高相关系数；（LI）=5.6（MI）^0.59。这是由于不同的分裂间期时间所致，其变异性可根据所提供的数据进行估算。
