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儿童低级别胶质瘤中 MIB-1 标记指数作为增殖活性标志物的预后效用和特征：一项回顾性观察研究。

Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study.

机构信息

Department of Hematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany.

Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, Tübingen, Germany.

出版信息

J Cancer Res Clin Oncol. 2024 Apr 5;150(4):178. doi: 10.1007/s00432-024-05701-w.

DOI:10.1007/s00432-024-05701-w
PMID:38580878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10997709/
Abstract

PURPOSE

The prognostic utility of MIB-1 labeling index (LI) in pediatric low-grade glioma (PLGG) has not yet conclusively been described. We assess the correlation of MIB-1 LI and tumor growth velocity (TGV), aiming to contribute to the understanding of clinical implications and the predictive value of MIB-1 LI as an indicator of proliferative activity and progression-free survival (PFS) in PLGG.

METHODS

MIB-1 LI of a cohort of 172 nonependymal PLGGs were comprehensively characterized. Correlation to TGV, assessed by sequential MRI-based three-dimensional volumetry, and PFS was analyzed.

RESULTS

Mean MIB-1 LI accounted for 2.7% (range: < 1-10) and showed a significant decrease to 1.5% at secondary surgery (p = .0013). A significant difference of MIB-1 LI in different histopathological types and a correlation to tumor volume at diagnosis could be shown. Linear regression analysis showed a correlation between MIB-1 LI and preoperative TGV (R = .55, p < .0001), while correlation to TGV remarkably decreased after incomplete resection (R = .08, p = .013). Log-rank test showed no association of MIB-1 LI and 5-year PFS after incomplete (MIB-1 LI > 1 vs ≤ 1%: 48 vs 46%, p = .73) and gross-total resection (MIB-1 LI > 1 vs ≤ 1%: 89 vs 95%, p = .75).

CONCLUSION

These data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG.

摘要

目的

在小儿低级别胶质瘤（PLGG）中，MIB-1 标记指数（LI）的预后实用性尚未得到明确描述。我们评估了 MIB-1 LI 与肿瘤生长速度（TGV）的相关性，旨在帮助理解 MIB-1 LI 作为增殖活性和无进展生存期（PFS）的指标的临床意义和预测价值。

方法

对 172 例非室管膜 PLGG 队列的 MIB-1 LI 进行了全面特征描述。通过基于 MRI 的三维体积测量来评估 TGV，并对 TGV 与 PFS 进行分析。

结果

平均 MIB-1 LI 占 2.7%（范围：<1-10），在二次手术时显著降低至 1.5%（p=0.0013）。不同组织病理学类型之间的 MIB-1 LI 存在显著差异，且与诊断时的肿瘤体积相关。线性回归分析显示 MIB-1 LI 与术前 TGV 呈正相关（R=0.55，p<0.0001），而在不完全切除后，相关性显著降低（R=0.08，p=0.013）。对数秩检验显示，不完全切除后（MIB-1 LI>1%与≤1%：48 与 46%，p=0.73）和大体全切除后（MIB-1 LI>1%与≤1%：89 与 95%，p=0.75），MIB-1 LI 与 5 年 PFS 之间均无相关性。

结论

这些数据首次证实了 MIB-1 LI 与 PLGG 中可检测到的 TGV 之间存在相关性。与术前 TGV 相比，手术后 MIB-1 LI 和 TGV 之间相关性显著降低，可能导致 MIB-1 LI 在 PLGG 中的预后能力有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/24c7f38a7d28/432_2024_5701_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/9db5d4ef045a/432_2024_5701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/4db5fc17a3f4/432_2024_5701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/c24b199801ce/432_2024_5701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/3e15388e3a5b/432_2024_5701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/cbf89b01552d/432_2024_5701_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/24c7f38a7d28/432_2024_5701_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/9db5d4ef045a/432_2024_5701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/4db5fc17a3f4/432_2024_5701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/c24b199801ce/432_2024_5701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/3e15388e3a5b/432_2024_5701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/cbf89b01552d/432_2024_5701_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2ea/11793602/24c7f38a7d28/432_2024_5701_Fig6_HTML.jpg

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