Jay V, Laperriere N, Perrin R
Department of Pathology, Ontario Cancer Institute/Hospital for Sick Children, University of Toronto, Canada.
Acta Neuropathol. 1991;82(5):420-4. doi: 10.1007/BF00296555.
Except for isolated case reports, blastomycosis has not been identified as a significant problem in immunosuppressed patients. We describe an unusual case with blastomycotic infection of a cerebral glioma in a 56-year-old man who underwent radiotherapy for his tumor and died of fulminant blastomycotic pneumonia. This is believed to be the first reported case of Blastomyces dermatitidis infection of a cerebral glioma. The light microscopic and ultrastructural features of B. dermatitidis, the giant forms of which were encountered in our patient, are described, and thr role of immunosuppression due to steroid therapy in the pathogenesis of this fulminant infection are reviewed.
除了个别病例报告外，芽生菌病在免疫抑制患者中尚未被确认为一个重大问题。我们描述了一例不寻常的病例，一名56岁男性的脑胶质瘤发生了芽生菌感染，该患者因肿瘤接受了放疗，最终死于暴发性芽生菌肺炎。据信这是首例关于脑胶质瘤感染皮炎芽生菌的报告病例。本文描述了在我们的患者中发现的皮炎芽生菌的光镜和超微结构特征，其巨大形态也在患者中被发现，并回顾了类固醇治疗引起的免疫抑制在这种暴发性感染发病机制中的作用。
