Chow S, Goldstein E J, Brody N
Cutis. 1981 Nov;28(5):572-4.
A 49-year-old man with sarcoidosis presented with a large nonhealing verrucous and eroded lesion (of two years' duration) over the left flank. Biopsy of the lesion revealed granulomatous infiltration, and special fungal stains showed the typical broad-necked budding structure of Bastomyces dermatitidis. The patient underwent en masse surgical removal of the lesion followed by systemic administration of amphotericin B. This report emphasizes the need for skin biopsy for nonhealing ulcers of unknown etiology, reviews the natural history of North American blastomycosis, and speculates on its relationship to immunosuppression.
一名49岁的结节病男性患者，左侧胁腹有一个持续两年不愈合的巨大疣状糜烂性病变。病变活检显示肉芽肿浸润，特殊真菌染色显示皮炎芽生菌典型的宽颈芽生结构。患者接受了病变整块手术切除，随后全身应用两性霉素B。本报告强调对于病因不明的不愈合溃疡进行皮肤活检的必要性，回顾北美芽生菌病的自然史，并推测其与免疫抑制的关系。
