Nathanson Jeffrey W, Yadron Nicole E, Farnan Jeanne, Kinnear Sydney, Hart John, Rubin David T
Reva and David Logan Gastrointestinal Clinical Research Center at the University of Chicago, Chicago, IL, USA.
Dig Dis Sci. 2008 Feb;53(2):474-80. doi: 10.1007/s10620-007-9886-1. Epub 2007 Aug 4.
Mutations in the tumor suppressor gene p53 are associated with neoplasia in ulcerative colitis, but little is understood of their significance in Crohn's disease (CD).
To explore p53 expression as a marker of neoplasia in CD patients.
This is a retrospective review of CD patients who underwent p53 IHC staining in our center between 1995 and 2003. The p53 status was correlated to the presence and grade of neoplasia at the time of staining and in subsequent follow-up.
Fourteen CD patients had p53 assessment: eight were p53 positive and six were p53 negative. Seven of eight p53+ had dysplasia (six LGD, one HGD); one of six p53-had dysplasia (LGD) (P = 0.03). Four p53+ patients with follow-up had persistent dysplasia and two had progression to a higher grade. Three p53- patients with follow-up remained free of dysplasia.
This limited study shows that p53 over expression in CD patients is associated with dysplasia that may progress to a higher grade of neoplasia over time.
肿瘤抑制基因p53的突变与溃疡性结肠炎的肿瘤形成有关，但对其在克罗恩病（CD）中的意义了解甚少。
探讨p53表达作为CD患者肿瘤形成标志物的情况。
这是一项对1995年至2003年间在本中心接受p53免疫组化染色的CD患者的回顾性研究。p53状态与染色时及后续随访时肿瘤形成的存在情况和分级相关。
14例CD患者接受了p53评估：8例p53阳性，6例p53阴性。8例p53阳性患者中有7例有发育异常（6例低级别发育异常，1例高级别发育异常）；6例p53阴性患者中有1例有发育异常（低级别发育异常）（P = 0.03）。4例接受随访的p53阳性患者存在持续性发育异常，2例进展为更高级别。3例接受随访的p53阴性患者未出现发育异常。
这项有限的研究表明，CD患者中p53的过度表达与发育异常有关，随着时间的推移，这种发育异常可能进展为更高级别的肿瘤形成。
