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子宫内膜异位症女性腹膜液的蛋白质组学分析。

Proteomic analysis of peritoneal fluid in women with endometriosis.

作者信息

Ferrero Simone, Gillott David J, Remorgida Valentino, Anserini Paola, Leung Kit-Yi, Ragni Nicola, Grudzinskas Jurgis G

机构信息

Reproductive Physiology Laboratory, St. Bartholomew's School of Medicine & Dentistry, Queen Mary University of London, United Kingdom.

出版信息

J Proteome Res. 2007 Sep;6(9):3402-11. doi: 10.1021/pr060680q. Epub 2007 Aug 3.

DOI:10.1021/pr060680q
PMID:17676783
Abstract

This study aims to evaluate differences in the expression of proteins present in the peritoneal fluid (PF) of women with and without endometriosis. PF samples were subjected to two-dimensional gel electrophoresis; protein spots of interest were identified by liquid chromatography tandem mass spectrometry. Several molecules had aberrant expression in PF of women with endometriosis; they may be useful for a better understanding of the pathogenesis of this disease.

摘要

本研究旨在评估患有和未患有子宫内膜异位症的女性腹膜液（PF）中蛋白质表达的差异。对PF样本进行二维凝胶电泳；通过液相色谱串联质谱法鉴定感兴趣的蛋白质斑点。几种分子在患有子宫内膜异位症的女性的PF中表达异常；它们可能有助于更好地理解这种疾病的发病机制。

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