来自杂交软珊瑚大花叉节珊瑚（Sinularia maxima x Sinularia polydactyla）的细胞毒性二萜类化合物。

Cytotoxic diterpenoids from the hybrid soft coral Sinularia maxima x Sinularia polydactyla.

作者信息

Kamel Haidy Nasr, Ferreira Daneel, Garcia-Fernandez Luis F, Slattery Marc

机构信息

Department of Pharmacognosy, and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.

出版信息

J Nat Prod. 2007 Aug;70(8):1223-7. doi: 10.1021/np070074p. Epub 2007 Aug 4.

DOI:10.1021/np070074p

PMID:17676898

Abstract

Chemical investigation of the hybrid soft coral Sinularia maxima x Sinularia polydactyla yielded four new cembranolide diterpenes (1-4), the norcembranoid 5-episinuleptolide (5), and two known sesquiterpenes. The structures and configurations of the new compounds were determined by spectroscopic techniques and comparison of NMR data with those of related metabolites. Compound 3 shows strong cytotoxicity on the breast cancer SK-BR3 cell line and cervix cancer HeLa and HeLa-Apl cell lines with GI(50) values of 0.039, 0.48, and 0.56 microM, respectively.

摘要

对杂交软珊瑚大花棘柳珊瑚×多指棘柳珊瑚进行化学研究，得到了4个新的西松烷型二萜（1 - 4）、降西松烷型5 - 表异柳珊瑚醇内酯（5）以及2个已知的倍半萜。通过光谱技术以及将核磁共振数据与相关代谢物的数据进行比较，确定了新化合物的结构和构型。化合物3对乳腺癌SK - BR3细胞系、宫颈癌HeLa和HeLa - Apl细胞系表现出较强的细胞毒性，其GI(50)值分别为0.039、0.48和0.56微摩尔。