Zhang Cui-Xian, Yan Su-Jun, Zhang Guang-Wen, Lu Wei-Gang, Su Jing-Yu, Zeng Long-Mei, Gu Liang-Quan, Yang Xiao-Ping, Lian Yong-Ju
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
J Nat Prod. 2005 Jul;68(7):1087-9. doi: 10.1021/np058006v.
The soft coral Sinularia microclavata collected from the bay of Sanya, Hainan Island, China, yielded a new diterpenoid, microclavatin (1), and a known cembranolide, capillolide (2). The structure of compound 1 was determined on the basis of spectroscopic methods and X-ray single-crystal diffraction analysis. Microclavatin (1) showed cytotoxic activities against tumor cell lines KB and MCF with IC50 values of 5.0 and 20.0 microg/mL, respectively, and capillolide (2) showed potent cytotoxic activity against tumor cell lines (A-549) with an IC50 value of 0.5 microg/mL.
从中国海南岛三亚湾采集的软珊瑚微小棘软珊瑚（Sinularia microclavata）中分离得到一个新的二萜类化合物——微小棘软珊瑚素（1）和一个已知的西松烷型二萜内酯——毛蒿素（2）。通过光谱方法和X射线单晶衍射分析确定了化合物1的结构。微小棘软珊瑚素（1）对肿瘤细胞系KB和MCF显示出细胞毒性活性，IC50值分别为5.0和20.0 μg/mL，而毛蒿素（2）对肿瘤细胞系（A-549）显示出较强的细胞毒性活性，IC50值为0.5 μg/mL。
