乙酰内酯，一种从软珊瑚 Acerosa 拟软柳珊瑚中提取的新型细胞毒性西松烷型二萜内酯。

Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa.

作者信息

Montalvo David, Amade Philippe, Funel-Le Bon Corinne, Fernández Rogelio, Reyes Fernando

机构信息

Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain.

出版信息

Nat Prod Res. 2006 May 20;20(6):548-52. doi: 10.1080/14786410500183274.

DOI:10.1080/14786410500183274

PMID:16835086

Abstract

A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines.

摘要

从软珊瑚 Acerosa 拟软柳珊瑚的 2-丙醇提取物中分离出一种新的西松烷型二萜内酯——刺柳珊瑚内酯（1）以及已知化合物假蕨素（2）。通过详细的光谱分析确定了 1 的结构。化合物 1 对 14 种肿瘤细胞系的体外细胞毒性表现为中等。