Hizuka N, Takano K, Asakawa K, Fukuda I, Sukegawa I, Shizume K, Demura H
Department of Medicine, Tokyo Women's Medical College, Japan.
Adv Exp Med Biol. 1991;293:105-12. doi: 10.1007/978-1-4684-5949-4_10.
Total and free form of IGF-I in plasma increased in a dose dependent manner after sc IGF-I administration. Peak values of total IGF-I were obtained at 3-4 h after the administration, and then the values decreased gradually. However, peak values of free form of IGF-I were obtained at 2 h, and then rapidly decreased thereafter. The blood glucose, serum insulin and C-peptide levels decreased until 4 h after IGF-I administration in a dose dependent manner. Plasma IGF-II values significantly decreased at 4-12 h after IGF-I administration. Urinary urea nitrogen and sodium excretion decreased after IGF-I administration. Urinary GH excretion also decreased after 0.06 mg/kg IGF-I administration. These data demonstrate that IGF-I may play a role in glucose, protein and electrolyte metabolism, and plasma IGF-II levels and GH secretion might be regulated by IGF-I in man.
皮下注射胰岛素样生长因子-I（IGF-I）后，血浆中IGF-I的总量和游离形式均呈剂量依赖性增加。注射后3-4小时获得总IGF-I的峰值，然后该值逐渐下降。然而，游离形式的IGF-I在2小时时达到峰值，此后迅速下降。血糖、血清胰岛素和C肽水平在IGF-I注射后4小时内呈剂量依赖性下降。IGF-I注射后4-12小时，血浆IGF-II值显著下降。IGF-I注射后尿尿素氮和钠排泄减少。0.06mg/kg IGF-I注射后尿生长激素排泄也减少。这些数据表明，IGF-I可能在葡萄糖、蛋白质和电解质代谢中起作用，并且血浆IGF-II水平和生长激素分泌可能在人体内受IGF-I调节。
