Takano K, Hizuka N, Asakawa K, Sukegawa I, Shizume K, Demura H
Department of Medicine, Tokyo Women's Medical College, Japan.
Endocrinol Jpn. 1990 Apr;37(2):309-17. doi: 10.1507/endocrj1954.37.309.
Recombinant human insulin-like growth factor I (IGF-I) was administered subcutaneously to each of 5 normal human subjects at doses of 0 mg/kg (control), 0.06 mg/kg, or 0.12 mg/kg successively at one week intervals. After 0.06 mg/kg or 0.12 mg/kg IGF-I injections, plasma IGF-I levels increased from 185 +/- 17 ng/ml (mean +/- SEM) to maximal levels of 396 +/- 21 ng/ml at 3 hours and from 169 +/- 14 ng/ml to 480 +/- 27 ng/ml at 4 hours, respectively. These two peak values were statistically different (p less than 0.05). After 0.06 mg/kg and 0.12 mg/kg IGF-I administration, blood glucose levels decreased from 85 +/- 2 mg/dl to minimal levels of 73 +/- 3 mg/dl at 3 hours and from 83 +/- 1 mg/dl to 50 +/- 4 mg/dl at 2 hours, respectively. These two minimal values were statistically different (p less than 0.001). Serum insulin and C-peptide levels were decreased in a dose dependent manner after IGF-I administration. There were no changes between blood urea nitrogen levels before and 4 hours after IGF-I administration. The urinary GH concentration decreased after 0.06 mg/kg IGF-I administration, but increased and maintained normal values after 0.12 mg/kg IGF-I administration.
重组人胰岛素样生长因子I（IGF-I）以0毫克/千克（对照）、0.06毫克/千克或0.12毫克/千克的剂量，每隔一周依次皮下注射给5名正常人类受试者。在注射0.06毫克/千克或0.12毫克/千克IGF-I后，血浆IGF-I水平分别在3小时从185±17纳克/毫升（平均值±标准误）升至最高水平396±21纳克/毫升，在4小时从169±14纳克/毫升升至480±27纳克/毫升。这两个峰值在统计学上有差异（p<0.05）。在给予0.06毫克/千克和0.12毫克/千克IGF-I后，血糖水平分别在3小时从85±2毫克/分升降至最低水平73±3毫克/分升，在2小时从83±1毫克/分升降至50±4毫克/分升。这两个最低值在统计学上有差异（p<0.001）。给予IGF-I后，血清胰岛素和C肽水平呈剂量依赖性降低。给予IGF-I前和给药后4小时血尿素氮水平无变化。给予0.06毫克/千克IGF-I后尿生长激素浓度降低，但给予0.12毫克/千克IGF-I后升高并维持在正常水平。
