树突状细胞在银屑病免疫发病机制中的作用。
The role of dendritic cells in the immunopathogenesis of psoriasis.
作者信息
Jariwala Sunit P
机构信息
Department of Internal Medicine, Albert Einstein/Montefiore Medical Center, 33 Teal Court, East Windsor, NJ 08520, USA.
出版信息
Arch Dermatol Res. 2007 Oct;299(8):359-66. doi: 10.1007/s00403-007-0775-4. Epub 2007 Aug 7.
Abstract
Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions.
摘要
寻常型银屑病是一种慢性炎症性皮肤病，其特征是树突状细胞（DCs）、T细胞、细胞因子和下游转录因子之间复杂的相互作用，这是自我维持的1型细胞因子网络的一部分。作为免疫系统的重要组成部分，DCs是抗原呈递细胞，对T细胞和B细胞的有效激活至关重要。DCs也与包括银屑病在内的多种慢性炎症性疾病有关。在银屑病治疗中，DC/T细胞相互作用是生物反应调节剂的潜在靶点。在此，我们描述了银屑病皮损背景下主要的DC亚群以及DCs的免疫参与情况。
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