Lowes Michelle A, Bowcock Anne M, Krueger James G
Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA.
Nature. 2007 Feb 22;445(7130):866-73. doi: 10.1038/nature05663.
Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
银屑病是人类最常见的皮肤疾病之一，被认为有关键的遗传基础。其特征为角质形成细胞过度生长和异常分化，但通过适当治疗可完全逆转。角质形成细胞反应的触发因素被认为是细胞免疫系统的激活，T细胞、树突状细胞以及各种免疫相关细胞因子和趋化因子都参与了发病机制。银屑病的最新疗法针对其免疫成分，可能为其他人类炎症性疾病预测潜在的治疗方法。
